Spandan Chaturvedi was born on c.25 August 2007 in Ulhasnagar, Mumbai, to Mr. Sunil Chaturvedi. She completed her first class studies in 2015. Chaturvedi is the cousin sister of Sparsh Khanchandani, who is also an actress.

Chaturvedi began her career with the 2012 Yash A Patnaik's drama series Ek Veer Ki Ardaas...Veera, in it she appeared in first few episodes, played the role of young Gunjan. Thereafter Chaturvedi appeared in several television advertisements. Later she played in Colors TV's programme Sanskaar - Dharohar Apnon Ki, where she played the role of Aarvi. Chaturvedi appeared as cameo in Disney Channel's comedy series The Suite Life of Karan & Kabir. In February 2014, Chaturvedi roped to play the daughter of Drashti Dhami's character in Ravindra Gautam's soap opera Madhubala – Ek Ishq Ek Junoon, in which she played the lead role of young Madhubala after twenty years leap in the show.

In August 2014, Chaturvedi featured to play the female protagonist in filmmaker Mahesh Bhatt's drama series Udaan, in which she is portraying the lead role of Chakor, a bonded labourer by birth, who faces challenges at the hands of Kamal Narayan (played by Sai Bilal), Fighting to be freed from the bonds of slavery after being mortgaged by her parents Kasturi (played by Sai Deodhar) and Bhuvan (played by Rajiv Kumar). She received fame and critical acclaim for her performance in the series,^[12][13] and won the Zee Gold Award for Best Child Actor, Television Style Award for Most Stylish Nanhe Natkhat and Indian Television Academy Award for Most Promising Child Star - Female (Desh Ki Ladli/Beti).^[14][15] While 100 episodes celebration, Chaturvedi injured herself when a marble table fell on her foot. She was hospitalized for at least ten days, and took one-and-a-half month to recover.^[16][17]

In February 2015, Chaturvedi appeared as a guest in K9 Productions comedy series Comedy Nights with Kapil on Colors TV.^[18] In April 2015, Chaturvedi appeared in the print campaign of GR8! Television Magazine, she appeared along with Gautam Gulati on the cover of magazine with the hashtag "BeWithBeti".^[19]

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