She is the daughter of Rono Mukerji and thus part of the Mukherjee-Samarth family. Her paternal uncle is Deb Mukherjee while her late paternal uncle were Joy Mukherjee and Shomu Mukherjee. Her paternal grandfather, Sashadhar Mukherjee, was a filmmaker. His wife Satirani Devi was the sister of Ashok Kumar, Anoop Kumar and Kishore Kumar. Her cousins are actresses Rani Mukerji, Kajol and Tanisha, director Ayan Mukerji and noted MIT algebraic geometer Davesh Maulik. Her brother Samrat Mukerji is also a Bollywood and Bengali actor.

Sharbani made her debut with the hit film Border. She was featured opposite Samir Soni in the song "Ghar Aaja Sonia" sung by Shazia Mansoor. She has also acted in various ads.^[3] By 2008 she shifted her focus into Mollywood, her debut Malayalam film Raakilipattu was released after 7 years of its production.She played the lead role in critically acclaimed film Sufi Paranja Katha.

• List of Bollywood Clans: The Mukherjees
• Mukherjee-Samarth family
• Mohnish Behl