Her father Suresh Deshpande was a noted writer and director of Marathi plays & films. Her mother Meena Deshpande is kathak alankar, dance teacher & theatre actress. Her sisterTemplate:Mrunal Deshpande is a Kathak Visharad and a known actress. Samidha tied the knot with Abhijit Guru , a well known writer, actor and director.|date=July 2015}}

Guru studied at M.P.D.S. Lokanchi Shala Nagpur. She has also completed BSc (Microbiology) along with BA (English literature) from LAD College, Nagpur. Before shifting to Mumbai, she had actively participated in theatre and also did a teaching job for a couple of years. After marriage, she came to Mumbai and got a break on small screen.

• Bhir Bhir (Upcoming)
• Laal ishq(2016)
• Panhala (2015)
• Kapuskondyachi Gosht (2014)
• Majha Mee (2014)
• Dhating Dhingana (2014)
• Tukaram (2013)
• Kaydyaach Bola (2010)^[7]

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• Get well Soon (Writer : Prashant Dalvi & Director : Chandrakant Kulkarni)
• Talyat Malyat (Written & Directed By: Abhijit Guru)

• Crime Petrol (Sony TV)
• Kamla (Colors Marathi)
• Devyani (Star Pravah)
• Gandha Fulancha Gela Sangun (Etv Marathi)
• Tujvin Sakhya Re (Star Pravah)
• Ghe Bharari (Me Marathi)
• vilakshan (Saam TV)
• Ya Valanavar (Etv Marathi)
• Jivalaga (Star Pravah)
• Zunj (Star Pravah)
• Avaghachi Sansar (Zee Marathi)
• Soniyacha Umbara^[7]
• Gane Tumche Aamche (Etv Marathi)

• Best Actress for Movie ‘Kapuskondyachi Gosht’ – Maharashtra State Awards 2014
• Best Actress for Movie ‘Kapuskondyachi Gosht’ – MaTa Sanman 2017
• Best Actress for Movie ‘Kapuskondyachi Gosht’ – Chitrapat Padarpan Awards 2017
• Best Actress for play ‘Get Well Soon’ – MMW Gaurav Awards 2014
• Nominated many times for her performances in film theatre & television.

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