Rajisha was born in Perambra, Kozhikode as the daughter of Sheela and Vijayan. She completed her graduation In Mass Communication and Journalism at Amity University, Noida, New Delhi. Apart from dancing, she kept high interest in theatre and athletics. She started working in Surya TV and later in Mazhavil Manorama as a television host.

2013–15

Rajisha was very popular among the television spectators through her shows. She also hosted Susi’s Code, a youth-centric programme and a music chat show which has gained popularity among the young generation.She hosted surya challenge alongwith Vidhu Pratap on Surya tv. She won the hearts of the TV viewers through her exceptional anchoring of Ugram Ujwalam, a talent show aired on Mazhavil Manorama.

2016–present

Rajisha debuted in the Malayalam Film Anuraga Karikkin Vellam for which she won several accolades. Her second project was the commercially successful movie Georgettan's Pooram alongside Dileep. Her next venture is Oru Cinemakaaran^[2] starring Vineeth Sreenivasan. She was adjudged the best actress in state in 2016 for her role in Anuraga Karikkin Vellam.