Neelu Vaghela started her career as a stage artist and was chosen for films. Neelu Vaghela movies which were super hits like Supattar Binani in 1981 at the age of 11. Neelu Vaghela acted in Bai Chali Saariya which was remade in Hindi as Saajan Ka Ghar where Juhi Chawla was the protagonist.

She acted in more than 50 films and 5 Gujarati films.

Famous movies in which acted were Ramgarh Ri Ramli, Jai Karni Mata, Naini Bai Ro Mayro, Lancha Gujri, Derani Jethani, Ramkudi Ghamkudi,Baisa Ra Jatan Karo, Dadosari Laadli, Veer Tejaji and Bai Chali Sasariye.

Neelu Vaghela is currently in gorai 2 borivali

Neelu Vaghela was also seem in Nach Baliye 5 with her husband Arvind Kumar. On 23 March 2013, Vaghela and her husband finished as 3rd place on the fifth season of Nach Baliye.

She is married to Arvind Kumar, and has two children - Kaizer and Vanshika.

• 2011-16 Diya Aur Baati Hum as Santosh Arun Rathi ("Bhabo")
• 2012-13 Nach Baliye 5 as Herself (contestant with husband Arvind Kumar)
• Meri Maa (Star Plus Mother's Day Special) as the Host
• 2017-Present Tu Sooraj, Main Saanjh Piyaji as Santosh Arun Rathi ("Bhabo")

• Ramgarh Ri Ramli
• Jai Karni Mata
• Naini Bai Ro Mayro as Naini Bai
• Lancha Gujri as Lancha Gujri
• Derani Jethani
• Ramkudi Ghamkudi as Ramkudi Ghamkudi
• Baisa Ra Jatan Karo
• Dadosari Laadli
• Veer Tejaji
• Bai Chali Sasariye
• Nanad Bhojai
• Supattar Binani