Hussey initially played for his native Western Australian Warriors, and his career total of 6471 runs ranks eighth in the list of that state's run-makers in the Sheffield Shield. He then moved to England, where in July 2001 he scored an unbeaten 329 (a Northamptonshire club record) at Wantage Road in his side's 633 for six declared on the way to a 10-wicket victory. He later captained Northamptonshire. In August 2003 he surpassed his own Northamptonshire record, when he scored 331 not out against Somerset at Taunton.

When Hussey was playing for Australia A, the Australian reserve team, Allan Border once jokingly suggested he get match practice by staying in the nets for a full six hours; surprisingly, Hussey went on to do just that.

Hussey earned a Cricket Australia contract in 2004–05 after excelling in the ING Cup. Statistically, Hussey's international career was very successful, with his career batting average in Tests being 51.52 and in ODIs 48.15. He was a very occasional medium pace bowler, bowling only 98 overs in his Test career, 23 of them in 2008. He was brought into the attack usually to give the pace bowlers a rest, although he was once brought on in India to stop Ricky Ponting getting a one-match ban for a slow over rate. On 28 December 2008, Day 3 of the Boxing Day test, he got his first test wicket, Paul Harris caught by Mitchell Johnson. He ended with figures of 1/22. He took two wickets in One Day Internationals.

One-day internationals

Hussey debuted for the Australian One-day team against India on 1