Hookes played for the West Torrens Cricket Club and made his A-Grade debut at the age of just 15. When he came in to bat he faced Adelaide Cricket Club bowler and local Australian rules football and media personality Ken "KG" Cunningham. KG said later in a Channel 9 tribute to Hookes that after the first two balls went past the edge of the bat, he walked down the wicket and attempted to upset the youngster in his first game and "gave him a huge spray". Hookes then sent the next four balls to the fence and after the over walked up to Cunningham and said: "Listen old man, if you continue to bowl those wobbly little inswingers the next four will go over the fence and not into the fence." In later years KG became one of Hookes's close friends and on Adelaide television and radio one of his strongest supporters even after his move to Melbourne to become coach of the Victorian state side.

David Hookes made his first-class debut in 1975–76 for South Australia. A rush of form in February 1977, when he scored five centuries from six innings in 17 days, led to his selection for the Centenary Test in March, 1977, at the age of 21.

Test debut and WSC

During Australia's second innings of the match, Hookes made 56, and hit Tony Greig for five consecutive boundaries. Soon after, he signed a contract with World Series Cricket (WSC) and then toured England. Playing all five Tests, Hookes compiled 283 runs at 31.44, with scores of 85 at The Oval and 50 at Lord's.

Hookes was one of the key personalities marketed by the breakaway WSC organisation. In a "Supertest" at the Sydney Showground in 1977, a bouncer from Andy Roberts broke his jaw, and his confidence never fully recovered from the injury. Nevertheless, he was the third-best performed Australian batsman behind Ian and Greg Chappell with 770 runs (at 38.5 average) in 12 "Supertests" played during the 1977–78 and 1978–79 seasons. His future in the Australian team following the rapprochement between WSC and official cricket seemed assured.

Problems post-WSC

However, Hookes managed just one Test and two ODIs when injury curtailed his 1979–80 season. Returned to fitness, he toured Pakistan in 1980, but made a pair in the first Test at Karachi, dismissed twice by spin bowler Iqbal Qasim. His play against slow bowling had not developed and he was vulnerable to the well-flighted delivery as his footwork was non-existent. Dropped from the Australian team, his form failed to improve in the following Australian season, and he lost his place in the South Australia team as well.

The SACA took a gamble by appointing Hookes as South Australia captain at the start of the 1981–82 season. He responded to the challenge and led the state to the Sheffield Shield. Improved confidence and form led to his reinstatement in the Australian team for the 1982–83 Ashes series, and he batted consistently for 344 runs at 49.14 average with a best score of 68 in the fourth Test at Melbourne. Continuing his good form on the follow